supp. che118b mt1 mascal
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1. Introduction - 0:00
The session starts with a greeting to participants and a brief overview of the session's topics.
2. Oxymercuration-demercuration Predict the Product Problem - 2:40
This segment covers how to predict the product of the oxymercuration-demercuration reaction involving alkenes.
3. Carbene Reactions - 5:19
Discusses the unique reactivity of carbenes in organic synthesis, highlighting their application in forming new bonds.
4. Preparation of Cyclopropane via Diazomethane - 8:45
Explains cyclopropane synthesis using diazomethane, illustrating the mechanism and conditions required.
5. Simmons-Smith Reaction - 10:41
This part details the Simmons-Smith reaction, a method for synthesizing cyclopropanes using a zinc-carbenoid intermediate.
6. Preparation of Dihalocyclopropane via Halogenated Carbene - 12:01
Describes the preparation of dihalocyclopropanes through the reaction of alkenes with halogenated carbenes.
7. Reaction of Peroxyacids - 14:19
Discusses the reaction mechanisms of peroxyacids with alkenes, leading to the formation of epoxides.
8. Isomerization Reaction and Mechanism - 19:06
Explains the isomerization of alkenes, including the catalysts and the mechanistic pathway.
9. Ring Expansion - 24:03
This segment explains the concept of ring expansion in cyclic compounds, particularly how it improves molecular stability.
10. Diastereoselectivity Reaction Example of Hydroboration-Oxidation - 30:47
Discusses the diastereoselective nature of the hydroboration-oxidation reaction, focusing on the outcomes based on substrate structure.
11. Radical Hydrobromination/Hydrosulfonation Reaction of Alkenes - 31:58
Explores the radical-initiated addition of hydrogen bromide and hydrogen sulfide to alkenes.
12. Oxymercuration-Demercuration Stereochemistry - 34:30
Examines the stereochemical outcomes of the oxymercuration-demercuration process, highlighting regio- and stereoselectivity.
13. E2 Predict the Product Problem (Anti-Periplanar Transition State) 1 - 38:06
Solves an E2 elimination problem, emphasizing the importance of the anti-periplanar transition state in determining the product.
14. E2 Predict the Product Problem (Anti-Periplanar Transition State) 2 - 41:14
Continues with another E2 elimination challenge, further discussing the role of molecular orientation in reaction mechanisms.
15. Hydration of Alkene in Alcohol Solvent - 42:59
Describes the hydration of alkenes using an alcohol solvent, detailing the process and its specific nuances.
16. Carbene Reactions Flowchart - 47:06
Presents a flowchart to help understand the various outcomes of reactions involving carbenes with different reagents.
17. Hydrogenation Stereoselectivity - 49:56
Discusses how stereoselectivity is achieved in the hydrogenation of alkenes and the factors influencing the outcome.
18. Hydrohalogenation (Addition of X2) to Alkenes - 52:19
Explores the addition of dihalogens to alkenes, detailing the reaction mechanism and expected products.
19. Alkene Nomenclature Problem 1 - 54:41
Presents a problem involving the nomenclature of alkenes, demonstrating how to correctly name a given alkene structure.
20. Alkene Nomenclature Problem 2 - 57:07
Continues with additional alkene nomenclature examples, providing insights into complex naming scenarios.
21. Alkene Nomenclature Problem 3 - 1:00:17
Concludes the series on alkene nomenclature, focusing on more advanced and tricky examples to solidify understanding.
1. Introduction - 0:00
The session starts with a greeting to participants and a brief overview of the session's topics.
2. Oxymercuration-demercuration Predict the Product Problem - 2:40
This segment covers how to predict the product of the oxymercuration-demercuration reaction involving alkenes.
3. Carbene Reactions - 5:19
Discusses the unique reactivity of carbenes in organic synthesis, highlighting their application in forming new bonds.
4. Preparation of Cyclopropane via Diazomethane - 8:45
Explains cyclopropane synthesis using diazomethane, illustrating the mechanism and conditions required.
5. Simmons-Smith Reaction - 10:41
This part details the Simmons-Smith reaction, a method for synthesizing cyclopropanes using a zinc-carbenoid intermediate.
6. Preparation of Dihalocyclopropane via Halogenated Carbene - 12:01
Describes the preparation of dihalocyclopropanes through the reaction of alkenes with halogenated carbenes.
7. Reaction of Peroxyacids - 14:19
Discusses the reaction mechanisms of peroxyacids with alkenes, leading to the formation of epoxides.
8. Isomerization Reaction and Mechanism - 19:06
Explains the isomerization of alkenes, including the catalysts and the mechanistic pathway.
9. Ring Expansion - 24:03
This segment explains the concept of ring expansion in cyclic compounds, particularly how it improves molecular stability.
10. Diastereoselectivity Reaction Example of Hydroboration-Oxidation - 30:47
Discusses the diastereoselective nature of the hydroboration-oxidation reaction, focusing on the outcomes based on substrate structure.
11. Radical Hydrobromination/Hydrosulfonation Reaction of Alkenes - 31:58
Explores the radical-initiated addition of hydrogen bromide and hydrogen sulfide to alkenes.
12. Oxymercuration-Demercuration Stereochemistry - 34:30
Examines the stereochemical outcomes of the oxymercuration-demercuration process, highlighting regio- and stereoselectivity.
13. E2 Predict the Product Problem (Anti-Periplanar Transition State) 1 - 38:06
Solves an E2 elimination problem, emphasizing the importance of the anti-periplanar transition state in determining the product.
14. E2 Predict the Product Problem (Anti-Periplanar Transition State) 2 - 41:14
Continues with another E2 elimination challenge, further discussing the role of molecular orientation in reaction mechanisms.
15. Hydration of Alkene in Alcohol Solvent - 42:59
Describes the hydration of alkenes using an alcohol solvent, detailing the process and its specific nuances.
16. Carbene Reactions Flowchart - 47:06
Presents a flowchart to help understand the various outcomes of reactions involving carbenes with different reagents.
17. Hydrogenation Stereoselectivity - 49:56
Discusses how stereoselectivity is achieved in the hydrogenation of alkenes and the factors influencing the outcome.
18. Hydrohalogenation (Addition of X2) to Alkenes - 52:19
Explores the addition of dihalogens to alkenes, detailing the reaction mechanism and expected products.
19. Alkene Nomenclature Problem 1 - 54:41
Presents a problem involving the nomenclature of alkenes, demonstrating how to correctly name a given alkene structure.
20. Alkene Nomenclature Problem 2 - 57:07
Continues with additional alkene nomenclature examples, providing insights into complex naming scenarios.
21. Alkene Nomenclature Problem 3 - 1:00:17
Concludes the series on alkene nomenclature, focusing on more advanced and tricky examples to solidify understanding.
