Why Are There So Many Antihistamines? 🤧💊

Antihistamine drugs are everywhere! While you’re used to the anti-allergy effects of commercially successful drugs like Benadryl and Claritin, popular drugs for motion sickness, peptic ulcers, and even antipsychotics started their lives as antihistamines. It also turns out that important concepts in pharmacology, like the receptor theory, and agonist and antagonist pharmacology, owe their development in part to the story of antihistamines.

☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️

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📜 S O U R C E S 📜
Full annotated script available for free on Patreon: https://www.patreon.com/posts/antihistamines-102208961
Blockbuster Drugs: the Rise and Decline of the Pharmaceutical Industry by Jie Jack Li https://amzn.to/3U4WnuM (affiliate link)
Ten Drugs by Thomas Hager https://amzn.to/4cFkZSj (affiliate link)
Histamine pharmacology: from Sir Henry Dale to the 21st century (2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012941/
Histamine receptors and antihistamines: from discovery to clinical applications (2014) https://pubmed.ncbi.nlm.nih.gov/24925401/
Histamine and itch (2014) https://www.ncbi.nlm.nih.gov/books/NBK200934/
Frontiers in Clinical Drug Research - Anti-Allergy Agents (2018) https://www.google.com/books/edition/Frontiers_in_Clinical_Drug_Research_Anti/EIJoDwAAQBAJ?hl=en&gbpv=0
Allergy https://www.ncbi.nlm.nih.gov/books/NBK545237/
Allergic rhinitis https://www.nature.com/articles/s41572-020-00227-0
Inverse Agonism and Functional Selectivity (2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165953/
Histamine H1 Receptor https://www.sciencedirect.com/topics/neuroscience/histamine-h1-receptor
Histamine and the antiallergic antihistamines: a history of their discoveries (1999) https://pubmed.ncbi.nlm.nih.gov/10444205/
Dale and Laidlaw isolate histamine (1910) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512903/pdf/jphysiol02557-0034.pdf
Dale and Richards experiment with histamine (1911) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402694/pdf/jphysiol01757-0036.pdf
Halpern discovers Phenergan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1591171/pdf/canmedaj00625-0017.pdf
The Claritin Effect; Prescription for Profit (2001) https://www.nytimes.com/2001/03/11/magazine/the-claritin-effect-prescription-for-profit.html
As Blockbuster Claritin Goes Generic, Schering-Plough Pushes a Close Sibling (2002) https://www.wsj.com/articles/SB1016748743581330920

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⌛T I M E S T A M P S ⌛
0:00 intro
0:34 The Discovery of Histamine
5:46 The First Antihistamines
12:33 The Rise of Non-Drowsy (Second Generation) H1 Antihistamines
19:34 Tagamet: the first blockbuster

#historyofmedicine #medicalhistory