Eukaryotic Transcription - Solving the Chromatin Problem

References/Resources: https://www.patreon.com/the_Crux

The process in the cycle of eukaryotic transcription that involves gaining access to the promoters because the genome of eukaryotes is packaged in the form of chromatin. Therefore, histones must be removed in order for GTFs and RNA polymerases to begin the initiation step. We discuss THREE MAIN MECHANISMS to solve this problem: CpG islands, NDR sites, and pioneer transcription factors. Finally, we also touch a bit on the role of enhancers to make the promoter regions more accessible.

Jump to your favorite section:
00:00 8 key steps
01:02 Chromatin Problem
02:37 CpG Islands
04:49 NDR sites
06:25 Pioneer Factors
08:10 Enhancers

Related videos -
Eukaryotic Transcription Introduction: https://youtu.be/QmTf4M4qrbI
Eukaryotic Promoter Video: https://youtu.be/tZEWEQib_F8
Prokaryotic Promoter Video: https://youtu.be/7AlpT7azzmE

***Playlists that you must explore***
Advanced concepts in Transcription: https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
Advanced concepts in Genetics: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IgEBW8xWPZhHSN4O8HXqQ6j
Journal Club: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IiRbmmqRbJdTskp4e5AhgrQ

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